A truncated form of DNA topoisomerase IIβ associates with the mtDNA genome in mammalian mitochondria
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چکیده
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an investigation of the types of text reduction in subtitling: a case study of the persian film gilaneh with english subtitles
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15 صفحه اولCleavage of DNA by Mammalian DNA Topoisomerase
Using the P4 unknotting assay, DNA topoisomerase I1 has been purified from several mammalian cells. Similar to prokaryotic DNA gyrase, mammalian DNA topoisomerase I1 can cleave double-stranded DNA and be trapped as a covalent protein-DNA complex. This cleavage reaction requires protein denaturant treatment of the topoisomerse 11-DNA complex and is reversible with respect to salt and temperature...
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DNA topoisomerases pass DNA strands through each other, a function essential for all DNA metabolic processes that create supercoils or entanglements of DNA. Topoisomerases play an ambivalent role in nuclear genome maintenance: Deficiency compromises gene transcription, replication and chromosome segregation, while the inherent DNA-cleavage activity of the enzymes endangers DNA integrity. Indeed...
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Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2-3% of patients treated with etoposide eventually develop treatment-related acute myeloid leukemias (t-AMLs) characterized by rearrangements of the MLL gene. The molecular basis underlying the development of these t-AMLs is not well understood; however, previous st...
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hMSCs (human mesenchymal stem cells) express two isoforms of DNA topo II (topoisomerase II). Although both isoforms have the same catalytic activity, they are specialized for different functions in the cell: while topo IIα is essential for chromosome segregation in mitotic cells, topo IIβ is involved in more specific cellular functions. A number of inhibitors are available that inhibit the cata...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2003
ISSN: 0014-2956
DOI: 10.1046/j.1432-1033.2003.03814.x